Naloxone is a safe medication that can reverse an opioid overdose in minutes. It should be widely available to everyone in the position to save a life.

In 2016, drug overdoses killed more Americans than car accidents, gun violence, and even breast cancer—making overdoses the leading cause of accidental death in the United States. 63,600 Americans died of a drug overdose in 2016—a 21% increase from the year before. And two-thirds of those deaths involved an opioid.1

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To combat the devastating effects of opioid overdose, many harm reduction programs have incorporated initiatives that promote the use of naloxone.

Naloxone is a medication that blocks opioid receptor sites to reverse the effects of an overdose and can be administered by nasal spray or injection into the muscle, under the skin, or intravenously.2 It has been approved by the FDA to prevent overdose involving opioids, including heroin and prescription painkillers.3 In some states, a prescription for naloxone is required, but others allow it to be sold over the counter.4

Policymakers and politicians are beginning to recognize the importance of harm reduction and the use of naloxone in the prevention of opioid overdose.

  • In early 2015, Secretary of Health and Human Services Sylvia Burwell announced an initiative that included changing the ways in which painkillers are prescribed, increasing the availability of medication-assisted treatment, and expanding naloxone usage to prevent overdose.5 
  • Later in 2015, President Obama announced new efforts to address prescription drug misuse, including expanding naloxone dispensing programs, training pharmacists on naloxone, educating law enforcement on naloxone, and more.6 
  • In 2016, the Attorney General announced the Department of Justice will support naloxone programs by increasing awareness with the “Law Enforcement Naloxone Toolkit” and by developing plans to expand access to naloxone.7

Naloxone access and training are a critical part of many harm reduction programs. By reversing overdoses and saving lives, naloxone gives those with substance use disorder another opportunity to learn to manage the disease.

Signs of an opioid overdose

Opioids affect the brain’s ability to regulate breathing.8 Using opioids in high levels can cause respiratory failure—which means breathing slows to the point that it stops, resulting in death.9 When someone is overdosing on opioids, they often exhibit some combination of three symptoms that the World Health Organization has named the “Opioid Overdose Triad”: pinpoint pupils, unconsciousness, and respiratory depression.10 

Additional symptoms of opioid overdose may include:11

  • Extreme paleness
  • Clammy skin
  •  A purplish or bluish hue to lips or fingernails
  • Vomiting
  • Gurgling noises
  • Limpness
  • An inability to be roused or awakened
  • An inability to speak
  • Slow breathing
  • Slow heartbeat

The sooner you recognize an opioid overdose and begin to treat it, the more likely your chances of reversing the effects and preventing death.12

What to do to reverse an overdose

As soon as you suspect someone has overdosed on opioids, call 911 to get help.13 If the person isn’t breathing, start CPR.14

The FDA has approved naloxone to prevent opioid overdose.15 If a naloxone kit or Narcan (the naloxone nasal spray) is available, administer it as soon as possible.

To use a naloxone auto-injection system like Evzio,16 remove the product from the packaging and firmly pull off the safety guard. Place the black end of the injector against the middle of the outer thigh of the person overdosing and hold it in place for five seconds. When it’s pressed, Evzio will click and hiss, which indicates it’s working correctly. After five seconds, the auto-injector needle will retract.

To use Narcan nasal spray, peel back the packaging and remove the product. Place two fingers on the nozzle and place your thumb on the plunger. Place the tip of the nozzle into the overdosing person’s nostril and press the plunger firmly to release the dose.17

After naloxone has been administered, continue CPR if necessary while waiting for the medication to kick in or for help to arrive.18 Naloxone wears off in 20-90 minutes, so it’s extremely important to get additional medical assistance to treat the overdose.

Learn more

Get a comprehensive overview of naloxone and how to use the various products available.

Learn More

Access to naloxone

From the World Health Organization19 to the White House,20 more and more policymakers are lending their support to making naloxone kits more accessible in the fight against opioid overdose. Research has shown that providing naloxone kits and minimal amounts of training to laypersons is effective at reducing deaths caused by overdose.21 One study showed that since 1996, nearly 26,500 opioid overdoses have been reversed thanks to the distribution of naloxone kits.22 These kits are also cost-effective23 and safe,24 and naloxone has been shown to have no potential for misuse.25

Naloxone kits are recommended for anyone who may be likely to witness an overdose, including friends and family members of those with opioid use disorders, first responders, law enforcement professionals, and other healthcare workers. Scotland, Ireland, and many states in the U.S. have policies of providing naloxone to anyone at risk of overdosing on opioids, as well as to those with a high probability of witnessing an overdose.26 Those who also participate in a naloxone training program are able to identify an overdose and respond,27 and minimal training of five to 10 minutes is needed.28

Every state has different laws about how naloxone can be dispensed. As of December 2016, 33 states and the District of Columbia allowed it to be sold by pharmacies without a prescription. Many states have also passed laws that exempt prescribers from any civil or criminal liability for prescribing, dispensing, or distributing naloxone, and 30 states have laws that exempt laypersons from civil or criminal liability when administering naloxone “in good faith.” Additionally, 37 states and the District of Columbia have “Good Samaritan” or “911 drug immunity” laws, which provide immunity from prosecution for drug possession or use when calling 911 or seeking follow-up care for an overdose.

What are the laws in your state?

For state-specific details about laws related to naloxone, visit the Policy Surveillance Program.

Learn More

Naloxone success stories

As of June 2014, there were at least 644 community-based programs in America that distributed naloxone to laypersons,29 including syringe exchanges, treatment facilities, primary care clinics, and pharmacies. These programs report nearly 26,500 overdose reversals between 1996 and 2014.30

There are naloxone programs run by law enforcement agencies in 29 states.31 In addition to saving lives, these programs have benefitted individual officers, who report feeling more satisfied with their ability to do something when they face an overdose, as well as the agencies overall, which report better community relations.32

The Bureau of Justice Assistance reports the success of several law enforcement agencies with naloxone programs.33 Since launching a law enforcement overdose reversal program in 2010, the Quincy Police Department in Massachusetts, for example, has reversed over 436 opioid overdoses. The Suffolk County Police Department in New York has over 1,300 certified officers who received training in the department’s Narcan program—and who have reversed 390 overdoses.

Similar success has been reported in programs around the world. Scotland’s National Naloxone Programme was associated with a 36% reduction in opioid-related deaths that occurred in the four weeks after a control group of prisoners with a history of drug use were released from prison.34 In its first 20 months, the British Columbia Naloxone Take Home Program reversed 85 overdoses.35 A New York City overdose prevention and naloxone administration training program reported an 83% success rate of people who survived when naloxone was administered.36

Since naloxone may be administered by other drug users in as many as 83% of cases37, many success stories go unheard and unreported. Clearly, when it comes to opioid overdose, naloxone is a powerful, necessary, and life-saving tool that plays an instrumental part in harm reduction.

Up Next:

Medication-Assisted Treatment

Read on
1. CDC. Drug Overdose Deaths in the United States, 1999-2016 . December 2017.
2. https://www.samhsa.gov/medication-assisted-treatment/treatment/naloxone
3. https://www.samhsa.gov/medication-assisted-treatment/treatment/naloxone
4. http://lawatlas.org/datasets/laws-regulating-administration-of-naloxone
5. “The Opioid Epidemic: By the Numbers” Department of Health and Human Services: https://www.hhs.gov/sites/default/files/Factsheet-opioids-061516.pdf
6. White House Fact Sheet: https://www.whitehouse.gov/the-press-office/2015/10/21/fact-sheet-obama-administration-announces-public-and-private-sector
7. Memo from the Office of the Attorney General: https://www.justice.gov/opioidawareness/file/896776/download
8. Yamanaka T , Sadikot “Opioid effect on lungs.” RT Respirology. 2013 Feb;18(2):255-62.
9. World Heath Organization “Information Sheet on Opioid Overdose” http://www.who.int/substance_abuse/information-sheet/en/
10. World Heath Organization “Information Sheet on Opioid Overdose” http://www.who.int/substance_abuse/information-sheet/en/
11. https://www.samhsa.gov/medication-assisted-treatment/treatment/opioid-overdose
12. Giglio et al “Effectiveness of bystander naloxone administration and overdose education programs: a meta-analysis” Injury Epidemiology 20152:10
13. https://www.samhsa.gov/medication-assisted-treatment/treatment/opioid-overdose
14. https://www.samhsa.gov/medication-assisted-treatment/treatment/opioid-overdose
15. https://www.samhsa.gov/medication-assisted-treatment/treatment/naloxone
16. https://evzio.com/patient/about-evzio/index.php#using-evzio
17. https://www.narcan.com/
18. https://www.narcan.com/
19. World Heath Organization “Information Sheet on Opioid Overdose” http://www.who.int/substance_abuse/information-sheet/en/
20, White House Fact Sheet: https://www.whitehouse.gov/the-press-office/2015/10/21/fact-sheet-obama-administration-announces-public-and-private-sector
21. Walley A, Xuan Z, Hackman HH, et al. Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ 2013;346:1–12.
22. CDC, MMWR, https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6423a2.htm?s_cid=mm6423a2_w
23. Coffin PO, Sullivan SD. Cost-effectiveness of distributing naloxone to heroin users for lay overdose reversal. Ann Intern Med 2013;158:1–9.
24. Doyon S, Aks SE, Schaeffer S. Expanding access to naloxone in the United States. Clin Toxicol (Phila) 2014;52:989–92.
25. Bureau of Justice Assistance Law Enforcement Naloxone Toolkit: https://www.bjatraining.org/tools/naloxone/Naloxone-Background
26. World Heath Organization “Information Sheet on Opioid Overdose” http://www.who.int/substance_abuse/information-sheet/en/
27. Traci C. Green , Robert Heimer , and Lauretta E. Grau “Distinguishing signs of opioid overdose and indication for naloxone: an evaluation of six overdose training and naloxone distribution programs in the United States” Addiction. 2008 Jun; 103(6): 979–989.
28. http://harmreduction.org/overdose-prevention/5-minutes-is-all-it-takes/
29. CDC, MMWR, https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6423a2.htm?s_cid=mm6423a2_w
30. CDC, MMWR, https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6423a2.htm?s_cid=mm6423a2_w
31. Bureau of Justice Assistance Law Enforcement Naloxone Toolkit: https://www.bjatraining.org/tools/naloxone/Naloxone-Background
32. Bureau of Justice Assistance Law Enforcement Naloxone Toolkit: https://www.bjatraining.org/tools/naloxone/Naloxone-Background
33. Bureau of Justice Assistance Law Enforcement Naloxone Toolkit: https://www.bjatraining.org/naloxone/what-are-some-success-stories-law-enforcement-overdose-reversal-programs
34. Bird, Shiela et al. “Effectiveness of Scotland's National Naloxone Programme for reducing opioid-related deaths: a before (2006–10) versus after (2011–13) comparison” Volume 111, Issue 5 May 2016 Pages 883–891
35. Banjo, Oluwajenyo et al. “A quantitative and qualitative evaluation of the British Columbia Take Home Naloxone program” CMAJ Open August 2014
36. Evaluation of a Naloxone Distribution and Administration Program in New York City. Tinka Markham Piper, Sharon Stancliff, Sasha Rudenstine, Susan Sherman, Vijay Nandi, Allan Clear, and Sandro Galea. Substance Use & Misuse Vol. 43 , Iss. 7,2008
37. https://www.nytimes.com/2016/07/28/us/naloxone-eases-pain-of-heroin-epidemic-but-not-without-consequences.html